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Autoantibodies even have the opportunity to bring about interference in troponin immunometric assay solutions. Fake-positive or false-unfavorable values might crop up, based upon whether the autoantibody-analyte elaborate partitions into the absolutely free or the certain analyte fraction.
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A meta-analysis of 14 studies confirmed which the specificity of the elevated troponin over the 99th percentile was drastically lowered in clients with CKD. It's critical to grasp Should the troponins are trending over time in these patients.[73] The troponin levels in patients with CKD are generally continuous, so a rise and fall with the troponin could well be extra indicative of the cardiac cause of the elevated troponin.
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